Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 52, Issue 12, Pages 1445-1450Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1445
Keywords
chiral ligand; diphosphine ligand; optical resolution; asymmetric hydrogenation; rhodium complex
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Axially chiral biphenyldiphosphine ligands bearing diphenylphosphino group(s) and/or dicyclohexylphosphino group(s) were prepared in enantiomerically pure form starting from 2,6-dimethylnitrobenzene via 8 steps: iodination, reduction, methoxylation through diazotization, Ullmann coupling, bromination, phosphorylation, optical resolution, and silane reduction, and the obtained ligands were used in rhodium-catalyzed asymmetric hydrogenation.
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