Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 51, Issue 12, Pages 2209-2211Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2004.834281
Keywords
ALS; motor units; MUNE; surface EMG
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The surface-recorded compound muscle action potential (CMAP) and electromyographic (EMG) interference pattern is used to compute the motor unit number index (MUNIX). The MUNIX demonstrated all known changes in the number of motor units in normal subjects, and in patients with amyotrophic lateral sclerosis (ALS). In normal subjects MUNIX decreased slightly with age and showed excellent reproducibility. In many ALS patients MUNIX was reduced even when the CMAP was normal. Lower MUNIX values were seen in weaker muscles. This is a noninvasive method that requires minimal electrical stimulation. It is performed in less than 5 min. This makes it suitable for serial EMG investigations.
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