Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 11, Pages 1970-1978Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/425582
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Funding
- NIAID NIH HHS [R56 AI052065, N01 AI 15123, R01 AI052065, R01 AI052065-01] Funding Source: Medline
- NICHD NIH HHS [P01 HD040539, P01 HD 40539] Funding Source: Medline
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Antibodies that mediate human immunodeficiency virus (HIV)-specific antibody-dependent cell-mediated cytotoxicity ( ADCC) are present in the cervical fluid of many HIV-positive women; however, the role that these antibodies play in host defense against HIV is not known. To understand the contribution of ADCC in cervical secretions as a protective mechanism against HIV, we evaluated ADCC titers in paired serum and cervical-lavage (CVL) samples from >300 HIV-1-positive women who participated in the multicenter Division of AIDS Treatment Research Initiative Study 009. The present study demonstrates that women with CVL ADCC activity had lower genital viral loads than did women with serum ADCC activity only. Women with CVL ADCC activity were likely to have HIV-1 gp120-specific immunoglobulin (Ig) G, but not IgA, in their cervical fluid. This finding suggests that specific IgG in cervical fluid can mediate ADCC activity that inversely correlates with genital viral load.
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