Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 11, Issue 12, Pages 11251-1252Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb866
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Funding
- NIGMS NIH HHS [GM67624] Funding Source: Medline
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Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I-anti.A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
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