Journal
FEMS MICROBIOLOGY LETTERS
Volume 241, Issue 1, Pages 87-93Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2004.10.008
Keywords
Staphylococcus lugdunensis; fibrinogen-binding; Sdr-family; LPXTG; clumping factor; phage display
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A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows, 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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