Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 53, Issue 12, Pages 1177-1182Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.45766-0
Keywords
-
Categories
Ask authors/readers for more resources
Burkholderia pseudomallei is the causative agent of melioidosis, which is a major cause of morbidity and mortality in endemic regions. Currently there is no human vaccine against melioidosis. In this study, LIPS or capsular polysaccharide was used to immunize BALB/c mice. The different polysaccharide, antigens induced antibody responses. Mice vaccinated with LIPS developed predominantly IgM and IgG3 responses. Contrastingly, mice vaccinated with capsular polysaccharide developed a predominantly IgG2b response. After immunization, mice were challenged by the intra-peritoneal route and an increased mean time to death was observed compared with unvaccinated controls. Immunization with LIPS provided an optimal protective response. Mice challenged by the aerosol route showed a small increase in the mean time to death compared with the unvaccinated controls. The passive transfer of antigen from immunized into naive mice provided protection against a subsequent challenge, This study is the first time antigens protective by active immunization have been identified and suggests that polysaccharides have potential as vaccine candidates against melioidosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available