Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 24, Pages 14012-14022Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.24.14012-14022.2004
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Funding
- NCRR NIH HHS [P51 RR000167] Funding Source: Medline
- NIAID NIH HHS [R01 AI049120, R01 AI052056, R01-AI-52056, R01-AI-46366, R01 AI046366, R01-AI-49120] Funding Source: Medline
- NIGMS NIH HHS [R01 GM043940, GM043940] Funding Source: Medline
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CD8(+) T lymphocytes (CD8-TL) select viral escape variants in both human immunodeficiency virus and simian immunodeficiency virus (SIV) infections. The frequency of CD8-TL viral escape as well as the contribution of escape to overall virus diversification has not been assessed. We quantified CD8-TL selection in SIV infections by sequencing viral genomes from 35 SIVmac239-infected animals at the time of euthanasia. Here we show that positive selection for sequences encoding 46 known CD8-TL epitopes is comparable to the positive selection observed for the variable loops of env. We also found that >60% of viral variation outside of the viral envelope occurs within recognized CD8-TL epitopes. Therefore, we conclude that CD8-TL selection is the dominant cause of SIV diversification outside of the envelope.
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