Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 50, Issue 4, Pages 247-251Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2004.07.011
Keywords
Scedosporium prolificans; liposomal amphotericin B; G-CSF
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Because human infections by Scedosporium prolificans are difficult to treat and show a very poor outcome, new therapeutic strategies are needed. Liposomal amphotericin B (LAMB) (40 mg/kg/day) increased significantly the mean survival time in immunosuppressed mice compared with a control group (22.6 vs. 8.8 days). Amphotericin B deoxycholate (1.5 mg/kg/day) and granulocyte colony-stimulating factor (G-CSF) (300 mug/kg/day) were ineffective. The combination of LAMB (40 mg/kg/day) and G-CSF (150 or 300 mug/kg/day) did not improve the results obtained with LAMB alone. (C) 2004 Elsevier Inc. All rights reserved.
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