Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 95, Issue 2-3, Pages 139-142Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.jep.2004.06.033
Keywords
Anacardium occidentale L.; anti-inflammatory; lipopolysaccharide; sepsis; microvascular permeability
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The methanol extract of Anacardium occidentale stem bark was evaluated for activities against the lipopolysaccharide (LPS)-induced septic shock, as well as LPS-induced microvascular permeability in mice. Pre-treatment with Anacardium occidentale extract (25-200 mg/kg) caused a dose-dependent and significant (p < 0.05) reduction in the elevated levels of alanine and aspartate aminotransferases in the sera of D-galactosamine-primed mice injected with LPS. The highest dose of the extract studied (200 mglkg) produced a 100% protection against death from sepsis. Pentoxifylline (100 mg/kg) and L-NAME (5 mg/kg) offered 100% protection against LPS-induced septic shock, and produced marked reduction in elevated levels of transferases. A dose-related inhibition of LPS-induced microvascular permability in mice was also produced by pentoxifylline, L-NAME and the extract. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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