Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 24, Pages 3100-3103Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4424-1
Keywords
mtDNA; mitochondria; calcium; cyclosporin A; membrane potential
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Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent release of the fragments of mitochondrial DNA could be one cause of genomic instability in the cell.
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