Journal
PEDIATRICS
Volume 114, Issue 6, Pages 1569-1573Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2003-0649-F
Keywords
insulin sensitivity; obesity; children; reduction of overweight
Categories
Ask authors/readers for more resources
Objective. Insulin sensitivity is impaired among some obese children, reflecting an atherogenic risk factor profile for the affected subjects. This study was performed to examine the amount of weight reduction required to improve insulin sensitivity. Methods. We studied changes in insulin sensitivity indices (ISIs) for glucose metabolism (homeostasis model assessment and quantitative insulin sensitivity check index) and fat metabolism ( free fatty acids) during a 1-year period among obese children who attended an obesity intervention program. The children were divided into 4 groups according to their changes in body mass index (BMI) SD score (SDS), as follows: group I, decrease in SDS-BMI of greater than or equal to0.5; group II, decrease in SDS-BMI of greater than or equal to0.25 to <0.5; group III, decrease in SDS-BMI of <0.25; group IV, increase in SDS-BMI. Results. Fifty-seven obese children (age range: 6-14 years; median age: 10 years; 46% boys) were included in the study. The 4 groups did not differ with respect to age, gender, degree of overweight (SDS-BMI), or ISI values at baseline. An increase in SDS-BMI (group IV, n = 12) was followed by a significant decrease in ISI values. The ISIs improved for group I ( n = 9), whereas there were no significant changes in these parameters for group II (n = 21) and group III (n = 15). Conclusions. During a 1-year period, an increase in weight among obese children was associated with a decrease in insulin sensitivity. Weight loss was followed by significant improvement in insulin sensitivity for glucose and fat metabolism but only if the SDS-BMI decreased by greater than or equal to0.5 during the 1-year period.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available