Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 6, Pages 653-662Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.09.012
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Funding
- NIA NIH HHS [R01 AG012282, AG12282] Funding Source: Medline
- NINDS NIH HHS [NS45093, R01 NS045093, R01 NS033376, NS33376] Funding Source: Medline
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The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways should be valuable in understanding the pathogenesis of, and ultimately in designing therapy for, neurodegenerative diseases that feature misfolded proteins.
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