Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II)

Copper(H) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, H-1 and C-13 NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu-11(2-BZP)(2)] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu-11(2-BZP)2] and [Pt-11(2-BZP)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 muM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 muM. While the Pill complexes may have damaged DNA to induce cell death, treatment with the Cull complex did not induce Jurkat cell death. (C) 2004 Elsevier Inc. All rights reserved.