Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 11, Pages 6537-6541Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.11.6537
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Funding
- NIAID NIH HHS [AI98903, AI51583] Funding Source: Medline
- NIDDK NIH HHS [DK45260] Funding Source: Medline
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IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL-15, in that cells bearing the IL-15Ralpha chain can bind soluble IL-15 and transpresent the cytokine to other cells, allowing the latter to respond to IL-15. However, it is unclear whether IL-15 is normally secreted and then becomes bound to surface IL-15Ralpha on bystander cells, or whether transpresentation is mediated by the same cells which synthesize IL-15. Using mixed bone marrow chimeric mice, we present evidence for the latter model, showing that development of NK cells and memory phenotype CD8 T cells necessitates that both IL-15 and IL15Ralpha be expressed by the same population of cells. These data argue that soluble forms of IL-15 are irrelevant for physiological responses to this cytokine, and the implications of this finding are discussed.
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