Journal
NATURE REVIEWS MICROBIOLOGY
Volume 2, Issue 12, Pages 946-953Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1046
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The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen-host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat.
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