Journal
MOLECULAR INTERVENTIONS
Volume 4, Issue 6, Pages 348-357Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/mi.4.6.8
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- NIGMS NIH HHS [GM 36927] Funding Source: Medline
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Rho signaling pathways in vascular smooth muscle cells are highly activated in hypertension, a condition associated with a variety of vascular diseases, including restenosis injury and atherosclerosis. In this review we suggest that inflammatory cytokines and agonists of G protein-coupled receptors That activate Rho are effective triggers of vascular disease. Accordingly. Rho kinase inhibitors and statins may have therapeutic potential for preventing vascular disease characterized by Rho-mediated cell proliferation and gene expression.
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