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ARC channels: A novel pathway for receptor-activated calcium entry

Journal

PHYSIOLOGY
Volume 19, Issue -, Pages 355-361

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00018.2004

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Funding

  1. NIGMS NIH HHS [GM-40457] Funding Source: Medline

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In many nonexcitable cells, stimulation with low agonist concentrations specifically activates Ca2+ entry via arachidonic acid-regulated, highly Ca2+-selective ARC channels. Only at high agonist concentrations are the more widely studied store-operated channels activated, producing sustained elevated cytosolic Ca2+ concentration signals. These signals activate calcineurin, which in turn inhibits the ARC channels, resulting in a reciprocal regulation of these two distinct Ca2+- entry pathways that may have important functional implications for the cell.

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