Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 287, Issue 6, Pages F1102-F1110Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00225.2004
Keywords
osmostress; tonicity enhancer/osmotic response element; tonicity enhancer binding protein; p38 kinase; ERK; JNK; osmolytes
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The adaptation to hypertonicity in mammalian cells is driven by multiple signaling pathways that include p38 kinase, Fyn, the catalytic subunit of PKA, ATM, and JNK2. In addition to the well-characterized tonicity enhancer ( TonE)-TonE binding protein interaction, other transcription factors ( and their respective cis elements) can potentially respond to hypertonicity. This review summarizes the current knowledge about the signaling pathways that regulate the adaptive response to osmotic stress and discusses new insights from yeast that could be relevant to the osmostress response in mammals.
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