4.4 Article

Two tonB systems function in iron transport in Vibrio anguillarum, but only one is essential for virulence

Journal

INFECTION AND IMMUNITY
Volume 72, Issue 12, Pages 7326-7329

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.12.7326-7329.2004

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Funding

  1. NIAID NIH HHS [AI 19018, R01 AI019018] Funding Source: Medline
  2. NIGMS NIH HHS [GM 64600, R01 GM064600] Funding Source: Medline

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We have identified two functional tonB systems in the marine fish pathogen Vibrio anguillarum, tonB1 and tonB2. Each of the tonB genes is transcribed in an operon with the cognate exbB and exbD genes in response to iron limitation. Only tonB2 is essential for transport of ferric anguibactin and virulence.

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