Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 27, Issue 12, Pages 1891-1894Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.1891
Keywords
neuro-immune interaction; mast cell; N-cadherin; confocal laser scanning microscopy; superiorcervical ganglin; beta-catenin
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Communication between nerves and mast cells is a prototypic demonstration of neuro-immune interaction. Numerous studies have shown that the stimulation of nerves (or addition of neurotransmitters) can evoke activation of mast cells, and that mast cell-derived mediators can influence neuronal activity. However. the molecules involved in the membrane-membrane contacts between nerves and mast cells are still unknown. Here. we used an in vitro co-culture approach comprising interaction between immune (bone marrow-derived mast cell. BMMC) and nerve cells (superior cervical ganglia, SCG). The experiments showed clearly that the nerve-mast cell communication was supported by synapse-like structure and that N-cadherin. not E-cadherin. played an essential role in the synapse-like structure. In addition, we found that the synapse-like structure was assisted by clustering of beta-catemn to N-cadherin.
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