Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 12, Pages 4889-4891Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.12.4889-4891.2004
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Funding
- NIGMS NIH HHS [R01 GM019756, F32 GM019756, GM 17975] Funding Source: Medline
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The effect of a number of antibiotics on stop codon readthrough during protein synthesis in Escherichia coli was examined. Inhibitors which bind close to the entrance of the peptide exit tunnel on the 50S ribosomal subunit promote substantial levels of readthrough, presumably by disrupting the mechanism of peptide release.
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