Journal
TRAFFIC
Volume 5, Issue 12, Pages 914-924Publisher
WILEY
DOI: 10.1111/j.1600-0854.2004.00244.x
Keywords
dense granule; falcipain; invasion; lysosome; microneme; plasmepsin; rhoptry; secretion; subtilase; toxopain
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Funding
- NIAID NIH HHS [T32 AI 07506, R01 AI 46985] Funding Source: Medline
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The Apicomplexan parasites Toxoplasma gondii and Plasmodium species are obligate intracellular parasites that rely upon unique secretory organelles for invasion and other specialized functions. Data is emerging that proteases are critical for the biogenesis of micronemes and rhoptries, regulated secretory organelles reminiscent of dense core granules and secretory lysosomes of higher eukaryotes. Proteases targeted to the Plasmodium food vacuole, a unique organelle dedicated to hemoglobin degradation, are also critical to parasite survival. Thus study of the targeting and function of the proteases of the Apicomplexa provides a fascinating model system to understand regulated secretion and secretory organelle biogenesis.
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