Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 16, Issue 6, Pages 808-814Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.09.017
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Funding
- NIAID NIH HHS [R01 AI033608, R01 AI33608] Funding Source: Medline
- NIGMS NIH HHS [R01 GM44809, R01 GM044809] Funding Source: Medline
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Random assembly of antibody variable (V), diversity (D) and joining (J) gene segments creates a vast repertoire of antigen receptors, including autoreactive ones. Three ways that are known to reduce autoreactivity in the B-cell compartment include clonal deletion, functional inactivation and receptor editing, a mechanism involving a change in antigen receptor specificity through continued V(D)J recombination. New data suggest that editing can efficiently eliminate autoreactivity, yet, in an autoimmune context, secondary antibody gene rearrangements might also contribute to autoimmunity.
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