Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 15, Issue 6, Pages 665-677Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.09.005
Keywords
junction; cadherin; armadillo protein
Categories
Funding
- NIAMS NIH HHS [R01AR43380, R01AR41836] Funding Source: Medline
- NIDCR NIH HHS [P01 DE12328] Funding Source: Medline
Ask authors/readers for more resources
Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available