Journal
NATURE IMMUNOLOGY
Volume 5, Issue 12, Pages 1227-1234Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1136
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Funding
- NIAID NIH HHS [R01 AI045927, AI09484, AI45927, R01 AI009484] Funding Source: Medline
- NINDS NIH HHS [R21 NS048866] Funding Source: Medline
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Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.
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