Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 26, Issue 6, Pages 385-391Publisher
SPRINGER
DOI: 10.1007/s00449-003-0328-y
Keywords
centrifugation; scale-down; shear; clarification
Funding
- Engineering and Physical Sciences Research Council [GR/R33878/01] Funding Source: researchfish
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Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge (TM)) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.
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