Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 7, Issue 6, Pages 610-616Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2004.10.011
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Gram-negative bacteria are bounded by two membranes. The outer membrane consists of phospholipids, lipopolysaccharides, lipoproteins and integral outer membrane proteins, all of which are synthesized in the cytoplasm. Recently, much progress has been made in the elucidation of the mechanisms of transport of these molecules over the inner membrane, through the periplasm and into the outer membrane, in part by exploiting the extraordinary capacity of Neisseria meningritidis to survive without lipopolysaccharide.
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