Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 6, Pages 647-652Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.09.009
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Mitochondria play an important role in the integration and transmission of cell death signals, activating caspases and other cell death execution events by releasing apoptogenic proteins from the intermembrane space. The BCL-2 family of proteins localize (or can be targeted) to mitochohdria and regulate the permeability of the mitochondrial outer membrane to these apoptotic factors. Recent evidence suggests that multiple mechanisms may regulate the release of mitochondrial factors, some of which depend on the action of caspases.
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