Journal
TETRAHEDRON LETTERS
Volume 45, Issue 50, Pages 9265-9268Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.10.049
Keywords
oxirane; alkynylation; regioselectivity; electronic effect; Lewis acid
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The electronic effect on the regioselectivity in the alkynylation of phenyloxiranes was investigated using three kinds of metal acetylides. BF3 mediated lithium acetylide provided either the alpha- or beta-alkynylated products by controlling the effect of the para-substituents of the phenyloxiranes. LiClO4 mediated lithium acetylide and titanium acetylide, on the other hand, afforded predominantly the beta- and alpha-products, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
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