Journal
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 271, Issue 1556, Pages 2523-2526Publisher
ROYAL SOC
DOI: 10.1098/rspb.2004.2897
Keywords
longevity; trade-off; daf-2 evolution
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Funding
- NIA NIH HHS [R01AG22868, R01 AG021069, R01AG21069] Funding Source: Medline
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An insulin/IGF-I-like signalling pathway determines the rate of aging of the adult nematode, Caenorhabditis elegans. Mutations in genes encoding this pathway can result in a doubling of lifespan. While such mutations may appear to have little effect on development or fertility, evolutionary theory predicts that large increases in lifespan will not be optimal for fitness. We demonstrate by laboratory natural selection that partial loss of function of the insulin receptor-like protein DAF-2 results in dramatically reduced fitness even under laboratory conditions. Despite long-lived mutants appearing healthy, they exhibit a heavy fitness cost consistent with an evolutionary theory of aging.
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