4.4 Article

Solvent dependent regioselective hydrogenation of substituted quinolines

Journal

SYNLETT
Volume -, Issue 15, Pages 2827-2829

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-835654

Keywords

hydrogenation; substituted quinolines; rhodium; solvent effects; HFIP

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Various substituted quinolines have been reduced under H-2 using Rh/Al2O3. Using methanol as solvent leads selectively to the 1,2,3,4-tetrahydroquinoline derivatives whereas in hexafluoroisopropanol the decahydro compounds are obtained.

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