4.8 Article

Cyclic sulfamidates as vehicles for the synthesis of substituted lactams

Journal

ORGANIC LETTERS
Volume 6, Issue 25, Pages 4727-4730

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol048036+

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A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and alpha-functionalized pyrrolidinone and piperidinone derivatives.

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