Metathesis polymerization-derived chromatographic supports

The synthesis and properties of metathesis polymerization-derived supports for solid-phase extraction (SPE), for the on-line extraction of metal ions, ion-chromatography, reversed-phase (RP-) chromatography, and chiral chromatography is described. In addition, the metathesis polymerization-based manufacture and derivatization of monolithic supports and their use in the separation of biomolecules such as oligonucleotides, thiooligonucleotides, double-stranded DNA (dsDNA) and proteins will be summarized. Special consideration will be given to important aspects of polymer chemistry and their relevance to the properties of these new supports. (C) 2004 Elsevier B.V. All rights reserved.