4.7 Article

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans

Journal

GENES & DEVELOPMENT
Volume 18, Issue 24, Pages 3004-3009

Publisher

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1255404

Keywords

aging; C. elegans; AMPK; insulin signaling; FOXO; energy levels

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Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP and functions to extend lifespan. In addition, either an environmental stressor that increases the AMP:ATP ratio or mutations that lower insulin-like signaling extend lifespan in an aak-2-dependent manner. Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals.

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