Journal
BIOLOGICAL PSYCHIATRY
Volume 56, Issue 12, Pages 931-937Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.09.013
Keywords
default state; familial; hypofrontality; resting; schizophrenia; self-representation; SPECT
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Funding
- NIMH NIH HHS [K24 MH001699-01A2, 1K24 MH 01699, 5P20 MH 50727, K24 MH001699] Funding Source: Medline
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Background: Schizophrenia is etiologically heterogeneous. It is anticipated, but unproven, that subgroups will differ in neuropathology and that neuroimaging may reveal these differences. The optimal imaging condition may be at rest, where greater variability is observed than during cognitive tasks, which more consistently reveal hypofrontality. We previously demonstrated symptom and physiological differences between familial and sporadic schizophrenia patients and hypothesized that the groups would show different resting regional cerebral blood flow (rCBF) patterns. Methods: Ten familial and sixteen sporadic schizophrenia patients and nine comparison subjects had single photon computed tomography imaging during passive visual fixation. Images were spatially normalized into Talairach coordinates and analyzed for group rCBF differences using SPM with a Z value threshold of 2.80, p >.001. Results: The subgroups had similar age, gender, illness duration, and medication treatment. Sporadic patients had hypofrontality (anterior cingulate, paracingulate cortices, left dorsolateral and inferior-orbitofrontal), whereas familial patients had left temporoparietal hypoperfusion; all of these regions show resting activity in healthy subjects. Both groups hyperperfused the cerebellum/pons and para parahippocampal gyrus; additional hyperperfusion for sporadic patients was observed in the fusiform; familial patients also hyperperfused the hippocampus, dentate, uncus, amygdala, thalamus, and putamen. Conclusions: Familial and sporadic schizophrenia patients bad cl different resting rCBF profiles, supporting The hypothesis that certain subgroups have distinct neural underpinnings. Different neuropathological processes among subgroups of schizophrenia patients may account for the prior contradictory results of resting imaging studies.
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