Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 12, Pages 7217-7222Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.12.7217
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Funding
- NIAID NIH HHS [T32 AI07529, R01 AI43619] Funding Source: Medline
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Induction of immunological tolerance is highly desirable for the treatment and prevention of autoimmunity, allergy, and organ transplant rejection. Adoptive transfer of MHC class I disparate mature T cells at the time of reconstitution of mice with syngeneic bone marrow resulted in specific tolerance to allogeneic skin grafts that were matched to the T cell donor strain. Mature allogeneic T cells survived long-term in reconstituted hosts and were able to re-enter the thymus. Analysis of T cell development using transgenic mice expressing an alloantigen-reactive TCR revealed that expression of allogeneic MHC class I on adoptively transferred mature T cells mediated negative selection of developing alloreactive T cells in the thymus. Thus, mature allogeneic T cells are able to mediate central deletion of alloreactive cells and induce transplantation tolerance without the requirement for any other alloantigen-expressing cell type.
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