Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 26, Pages 6447-6450Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049379g
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We describe the development of cell-permeable beta-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell-based assay (IC50 < 100 nM), these inhibitors display impressive selectivity against other biologically relevant aspartyl proteases.
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