Journal
VACCINE
Volume 23, Issue 5, Pages 615-622Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.07.014
Keywords
human; B lymphocytes; antibodies
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We assessed the avidity maturation process elicited by human immunization with alum-adsorbed HBsAg alone or with a novel adjuvant containing CpG motifs (CpG 7909). Mean avidity indexes and distribution of low- and high-avidity anti-HBs indicated that avidity manturation essentially takes place late after priming. CpG 7909 markedly enhanced this affinity maturation process, increasing the pool of high-activity antibodies. The influence of CpG 7909 was antigen-specific, isotype-specific and distinct from the influence on anti-HBs production, as avidity did not correlate with anti-HBs IgG titers. This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity. (C) 2004 Elsevier Ltd. All rights reserved.
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