Journal
TETRAHEDRON LETTERS
Volume 45, Issue 52, Pages 9611-9615Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.10.143
Keywords
2-oxazoline; isourea; Lewis acid; microwave irradiation; carbodiimide
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N-(beta-Hydroxy)amides can be cyclised by reaction with diisopropy1carbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5mol% Cu(OTf)(2)) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation. (C) 2004 Elsevier Ltd. All rights reserved.
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