Journal
ORGANIC LETTERS
Volume 6, Issue 26, Pages 4857-4860Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol048084u
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[Graphics] A bimodal target-specific contrast agent based on a cyclic peptide containing the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chemical ligation, and gives a straightforward approach for double labeling of peptides in general.
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