Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 52, Pages 18069-18074Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0407611102
Keywords
chromatin immunoprecipitation; mating; transcriptional circuit
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Funding
- NIGMS NIH HHS [R01 GM37049, R01 GM037049] Funding Source: Medline
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The budding yeast Saccharomyces cerevisiae has three cell types (a cells, alpha cells, and a/alpha cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.
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