Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Volume 359, Issue 1452, Pages 1945-1951Publisher
ROYAL SOC LONDON
DOI: 10.1098/rstb.2004.1564
Keywords
myosin; hair cells; mechanotransduction; adaptation; chemical genetics
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Funding
- NIDCD NIH HHS [P30 DC005983, R01 DC002387, R01 DC003279] Funding Source: Medline
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Twenty years ago, the description of hair-cell stereocilia as actin-rich structures led to speculation that myosin molecules participated in mechanical transduction in the inner ear. In 1987, Howard and Hudspeth proposed specifically that a myosin I might mediate adaptation of the transduction current carried by hair cells, the sensory cells of the ear. We exploited the myosin literature to design tests of this hypothesis and to show that the responsible isoform is myosin 1c. The identification of this myosin as the adaptation motor would have been impossible without thorough experimentation on other myosins, particularly muscle myosins. The sliding-filament hypothesis for muscle contraction has thus led to a detailed understanding of the behaviour of hair cells.
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