Journal
TETRAHEDRON LETTERS
Volume 46, Issue 1, Pages 177-180Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.10.170
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An efficient, microwave-assisted method for the mercury chloride mediated synthesis of 1,2-disubstituted benzimidazoles has been developed. Biologically interesting benzimidazoles were readily assembled utilizing SNAr reactions, reduction, and followed with mercury(II) mediated cyclization under microwave irradiation. The desired products were then liberated from the soluble matrix in excellent yield and purity after cleavage. (C) 2004 Elsevier Ltd. All rights reserved.
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