Journal
TETRAHEDRON LETTERS
Volume 46, Issue 1, Pages 153-156Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.10.162
Keywords
1-substituted-pyrrolidin-2-ones; 5-C-N bond formation; 1,5-disubstituted-pyrrolidin-2-ones; formylation; 1,3-disubstituted-pyrrolidin-2-ones
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A novel 5-C-N bond forming reaction is reported, which involves heating 1-substituted-pyrrolidin-2-ones with cyclic amines in the presence of a base. This reaction provides a convenient method for the synthesis of 1,5-disubstituted-pyrrolidin-2-ones. (C) 2004 Elsevier Ltd. All rights reserved.
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