Journal
FEBS LETTERS
Volume 579, Issue 1, Pages 259-264Publisher
WILEY
DOI: 10.1016/j.febslet.2004.11.085
Keywords
GPCR; cannabinoid; splice variant; anandamide; 2-arachidonoylglycerol; expression
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Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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