4.4 Article

Safe radical azidonation using polystyrene supported diazidoiodate(I)

Journal

TETRAHEDRON
Volume 61, Issue 1, Pages 123-127

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.10.040

Keywords

polymer supported reagent; radical substitution; solution phase combinatorial chemistry

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Aldehydes are converted to acyl azides and benzyl ethers to azido ethers by treatment with polymer supported iodine azide in MeCN at 83 degreesC. The reaction provides a safe and convenient alternative to the use of iodine azide in radical azidonations. (C) 2004 Elsevier Ltd. All rights reserved.

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