Journal
FEBS LETTERS
Volume 579, Issue 1, Pages 79-89Publisher
WILEY
DOI: 10.1016/j.febslet.2004.06.103
Keywords
protein synthesis inhibition; nucleic acid intercalator; translation; Hepatitis C virus internal ribosome entry site
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The use of small molecule inhibitors in the study of cellular processes is a powerful approach to understanding gene function. During the course of a high throughput screen for novel inhibitors of eukaryotic translation, we identified a number of nucleic acid binding ligands that showed activity in our assay. When tested on a panel of mRNA transcripts displaying different modes of translation initiation, these ligands showed a range of biological activities - with some inhibiting both cap-dependent and internal initiation and others preferentially blocking internal initiation. We used this information to identify a novel threading intercalator that inhibits Hepatitis C virus internal initiation. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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