Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1739, Issue 2-3, Pages 167-178Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2004.06.016
Keywords
Alzheimer's disease; neurofibrillary tangle; tau; folding intermediate; aggregation; kinetics
Funding
- NIA NIH HHS [AG14452] Funding Source: Medline
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New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed. (C) 2004 Elsevier B.V All rights reserved.
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