Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 36, Issue 5, Pages 989-994Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2004.08.026
Keywords
herbal medicines; phytopharmaceuticals; capillary electrophoresis; HPLC; gurana; adulterants
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The last years have seen a significant increase in the use of herbal medicines and their preparations all over the world. Adulterations with synthetic drugs are common problems with phytopharmaceutical products and this can potentially cause adverse effects. In consequence it is important to determine the presence of synthetic drugs in herbal medicines to ensure their efficacy and safety In this study guarana derivatives were analyzed by capillary electrophoresis (CE), and the results were compared with those obtained by the HPLC technique. In order to obtain adequate fingerprints, and search for adulterants, caffeine was used as the marker compound. This separation method was applied to analyze the seed powder and commercial tablets of Paulinia cupana Man. The methodology performance was evaluated in terms of specificity, sensitivity and precision. The results are in agreement with those obtained by the HPLC method. Furthermore. the analysis time of the CE method is up to two times shorter than the respective parameter in HPLC and solvent consumption is more than 100-fold less. (C) 2004 Elsevier B.V. All rights reserved.
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