Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 132B, Issue 1, Pages 65-69Publisher
WILEY-LISS
DOI: 10.1002/ajmg.b.30095
Keywords
replication; linkage; personality; anxiety; depression
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Funding
- NIDA NIH HHS [DA-10228] Funding Source: Medline
- NIMH NIH HHS [MH-059160] Funding Source: Medline
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Neuroticism is a personality factor that has consistently been demonstrated to be associated with anxiety, depression, and other internalizing disorders. We analyzed a genome scan for neuroticism on a sample of 129 sib-pair families (113 with a single sibling pair, 18 with multiple sibling pairs) containing a total of 201 possible sibling pairs, ascertained for concordance on nicotine dependence. Using Merlin-Regress, we replicated peaks for neuroticism described by prior studies, on chromosomes 1 and 11 with LOD scores of 2.52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014). (C) 2004 Wiley-Liss, Inc.
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